Role of On-Demand Therapy

Guidelines state on-demand treatment of attacks is most effective when administered early in the attack. Patients should be counseled to treat as soon as the attack is clearly recognized.1,8

The US HAE Medical Advisory Board states that all attacks, irrespective of location, should be considered for treatment as soon as they are clearly recognized. There is overwhelming consensus that all abdominal, facial, oral, and upper respiratory attacks should be treated as early as possible.1

Guidelines state patients who experience symptoms of laryngeal, tongue, or throat swelling should seek emergency medical care as soon as possible, even after initial self-treatment.1,8


[1] Zuraw BL, Banerji A, Bernstein JA, et al. US Hereditary Angioedema Association Medical Advisory Board 2013 recommendations for the management of hereditary angioedema due to C1 inhibitor deficiency. J Allergy Clin Immunol Pract. 2013;1(5):458-67.
[8] 2018 Maurer – The international WAO_EAACI guideline for the management of hereditary angioedema – the 2017 revision and updateREFERENCEvf1.14