Understanding Hereditary angioedema (HAE) triggers can help patients avoid those triggers.
Physical exertion involving a repetitive motion for long periods of time can place pressure on one part of the body that may induce an acute attack in HAE patients.
Mental stress can be a potential trigger for an HAE attack.3 HAE not only causes substantial short-term disability associated with attacks, but, in between attacks, patients may live in persistent anxiety and disappointment, being prevented from participating in selected activities. As such, patients experience substantial psychosocial burden living day-to-day with HAE.18 Mental health support or treatment may be necessary for certain individuals.3
Surgery, both medical and dental procedures, are examples of epithelial trauma. Dental surgery and tooth extractions can trigger the contact cascade, causing face, lip, cheek, laryngeal, and even abdominal edema.14
HAE symptoms can also be triggered by fluctuations in female hormones. The frequency of HAE attacks in women varies according to the different life stage—childhood, puberty, menses, pregnancies, and menopause. Combined oral contraceptives during the reproductive stage have also triggered HAE symptoms.15
While patients may be able to identify certain triggers, attacks do not always follow, making them difficult to predict.
Other Patient-Reported Triggers Include:
- Weather changes
- Medical/dental procedures
- Estrogen-containing oral contraceptive use